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Sunday, May 3, 2020 | History

4 edition of Antifolate drugs in cancer therapy found in the catalog.

Antifolate drugs in cancer therapy

Antifolate drugs in cancer therapy

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  • 8 Currently reading

Published by Humana Press in Totowa, N.J .
Written in English

    Subjects:
  • Folic acid -- Antagonists -- Therapeutic use.,
  • Cancer -- Chemotherapy.,
  • Antimetabolites -- Therapeutic use.,
  • Folic acid -- Derivatives -- Therapeutic use.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Ann L. Jackman.
    SeriesCancer drug discovery and development
    ContributionsJackman, Ann L.
    Classifications
    LC ClassificationsRC271.F6 A58 1999
    The Physical Object
    Paginationx, 456 p. :
    Number of Pages456
    ID Numbers
    Open LibraryOL20001659M
    ISBN 100896035964
    LC Control Number00501973


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Antifolate drugs in cancer therapy Download PDF EPUB FB2

In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs. The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate, other dihydrofolate reductase inhibitors, Author: Ann L.

Jackman. In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs. The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate, other dihydrofolate reductase inhibitors.

Antifolate drugs, such as the dihydrofolate reductase (DHFR) inhibitor methotrexate (MTX), have been used in the treatment of cancer for more than 50 years.

Increased understanding of the biochemistry of folate-dependent pathways, folate transporters, drug resistance, and downstream effects of target inhibition has led to the discovery of new.

In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs. The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate, other dihydrofolate reductase inhibitors,Brand: Humana Press.

Antifolate Drugs in Cancer Therapy by Ann L. Jackman,available at Book Depository with free delivery worldwide. In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs.

The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate. Recent years have seen two new antifolate drugs approved for marketing: trimetrexate (Neutrexin), a lipophilic inhibitor of dihydrofolate reductase (DHFR) for treatment of the life-threatening fungal infection, Pneumocystis carinii pneumonia; and the thymidylate synthase (TS) inhibitor, raltitrexed (Tomudex), for colorectal cancer.

In addition. The NCI Dictionary of Cancer Terms features 8, terms related to cancer and medicine. We offer a widget that you can add to your website to let users look up cancer-related terms.

Get NCI’s Dictionary of Cancer Terms Widget. Antifolate Drugs: Past and Future Perspectives, Robert C. Jackson. Folate Biochemistry and Nutrition in Relation to Antifolate Selectivity, Roy L. Kisliuk. Clinical Pharmacology and Resistance to Dihydrofolate Reductase Inhibitors, Richard Gorlick and Joseph R.

Bertino. While renewing tissues of the bone marrow and intestinal tract are also folate-dependent and are sites of antifolate toxicity, the clinical utility of antifolates was established with the identification of doses and schedules of administration that provided sufficient selectivity to make these drugs effective in the treatment of cancer as well.

Get this from a library. Antifolate drugs in cancer therapy. [Ann L Jackman;] -- In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs.

This page lists cancer drugs approved by the Food and Drug Administration (FDA) for lung cancer. The list includes generic and brand names. This page also lists common drug combinations used in lung cancer.

The individual drugs in the combinations are FDA-approved. However, the drug combinations themselves usually are not approved, although. PDF | 5 Fluorouracil (5FU) is a rationally designed antineoplastic agent (1,2) with distinct antifolate and antipyrimidine properties.

5FU is usually | Find, read and cite all the research you. Book reviews Book reviews, Eur J Clin Pharmacol () ± Ó Springer-Verlag Antifolate drugs in cancer therapy Ann L Jackman (ed) ; deserves a place on the shelf of any clinician or scientist involved in pp; hardcover £ ISBN Humana Press, the research or management of cancer.

The latter cells lack the capacity to synthesize folates. In some patients, high dosages of antifolate drugs (eg: methotrexate, pemetrexed) used in cancer chemotherapy alter the keratinocytes, endothelial cells and Factor XIIIa+ dermal dendrocytes in a range of various by: 4.

Pemetrexed disodium (ALIMTA ®, “pemetrexed”) is a novel, multi‐targeted antifolate that has demonstrated promising clinical activity in a wide variety of solid tumors, including non‐small cell lung, breast, mesothelioma, colorectal, pancreatic, gastric, bladder, cervix, and head and exed inhibits multiple folate‐dependent enzymes involved in both purine and pyrimidine Cited by: Request PDF | On Jan 1,Yongyuth Yuthavong and others published Antifolate Drugs | Find, read and cite all the research you need on ResearchGate.

Anticancer therapy is constantly changing; it has entered the postgenomic era, enabling a development of drugs that target cancer cells and do not harm the healthy cells. Specific targets in cancer cells available for potential treatment are presented, with a brief description how these targets can be identified, validated, and used in clinical.

Free 2-day shipping. Buy Cancer Drug Discovery & Development: Antifolate Drugs in Cancer Therapy (Hardcover) at nd: Ann L Jackman. Book 8 -ANTINEOPLASTIC DRUGS Third Edition Prepared by Evelyn M.

Shambaugh, M.A., CTR children with acute lymphoblastic leukemia led to the development of antifolate agents in the early 's.

This new approach to cancer therapy made it possible to File Size: 6MB. Pemetrexed is a newly approved antifolate agent for the treatment of malignant pleural mesothelioma (MPM) and metastatic non-small cell lung cancer (NSCLC).

We performed a PubMed/MEDLINE database search to identify relevant literature from January April Folate pathways are essential in metabolism and macromolecule synthesis.

Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the. Access: Online book. Radioimmunoassay in Basic and Clinical Pharmacology.

Published: Access: Online book. Handbook of psychiatric drug therapy. Antifolate Drugs in Cancer Therapy. By: Jackman, Ann L Published: Access: Online book.

Sidney Farber (Septem – Ma ) was an American pediatric is regarded as the father of modern chemotherapy for his work using folic acid antagonists to combat leukemia, which led to the development of other chemotherapeutic agents against other was also active in cancer research advocacy and fundraising, most notably Born: SeptemBuffalo, New York.

Although several antifolate drugs have been developed, MTX is the antifolate with the widest spectrum of use. MTX is extensively used in lymphoma, ALL and osteosarcoma. Moreover, MTX is part of chemotherapeutic schemes for choriocarcinoma, breast, bladder and head and neck cancer [ 27 ].Cited by: 6.

Targeted Drug Strategies for Cancer and Inflammation: Medicine & Health Science Books @   Pemetrexed (ALIMTA, LY, MTA) is a novel antimetabolite that inhibits at least three enzymes involved in the folate pathway. These enzymes are thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase.

Pemetrexed has demonstrated clinical activity in non-small cell lung cancer as well as in a broad array of other solid tumors, including Cited by: antifolate chemotherapy: Antifolate therapy Oncology The use of an antimetabolite–eg, MTX, to compete with folate, inhibiting dihydrofolate reductase, the enzyme responsible for → inactive dihydrofolate into an active tetrahydrofolate; this block causes a buildup of toxic dihydrofolate, shutting down synthesis of purine nucleotides and.

(see, generally, Antifolate Drugs in Cancer Therapy, edited by Jackman, Ann L., Humana Press, Totowa, N.J., ) In some cases, a supportive intervention is routinely used to permit safe, maximal dosing.

For example, steroids, such as dexamethone, can be used to prevent the formation of skin rashes caused by the antifolate.

(Antifolate, pg ). The expense of developing cancer drugs, and their cost to patients and insurers, would clearly be worth it if the drugs promised cures or even deep remissions, but the vast majority of new drugs.

Purpose: Highly aggressive triple-negative breast cancers (TNBCs) lack validated therapeutic targets and have high risk of metastatic disease. Folate receptor alpha (FRα) is a central mediator of cell growth regulation that could serve as an important target for cancer therapy.

Experimental Design: We evaluated FRα expression in breast cancers by genomic (n = 3,) and Cited by: 7. Antiangiogenic Agents in Cancer Therapy. Beverly A. Teicher, ed. Totowa (NJ): Humana Press, pp., illus.

$ISBN Antifolate Drugs in Cancer. Drugs called antifolates have been used for decades in chemotherapy to starve cancer cells of folate, which can help kill the tumor. These drugs have also been used to treat inflammatory diseases like rheumatoid arthritis and Crohn’s disease.

Additionally, antifolate drugs, such as methotrexate (MTX) and pemetrexed (PMX), modify folate/Hcy metabolism. The relationships between folate phenotype, genetic polymorphisms of folate pathway enzymes, and inflammatory proteins were examined in both population-based and cell culture : Andrea L.

Hammons. Undoubtedly, unravelling the mechanism of the resistance of melanomas to this drug could help to improve current therapeutic approaches.

Moreover, it could help to develop a novel generation of antifolate drugs that overcome resistance problems and present low toxicity for the prophylaxis and treatment of by: 2. Antimetabolites in cancer chemotherapy 1.

By ORIBA DAN LANGOYA MBchB 2. ANTIFOLATES Methotrexate Is a folic acid analog that binds with high affinity to the active catalytic site of DHFR. This results in inhibition of the synthesis of tetrahydrofolate (THF).

Inhibition of metabolic processes interferes with the formation of DNA, RNA, and key cellular proteins. DOI: /JCO Journal of Clinical Oncology - published online before print Septem PMID: Multitargeted Antifolate LY as First-Line Chemotherapy for Patients With Advanced Non–Small-Cell Lung Cancer: A Phase II StudyCited by:   It was shown previously that antifolate treatment resulted in an upregulation of α-FR expression in HT cancer cell cultures because of interference of the antifolates with folate metabolism.

Thus, we speculated that antifolate pretreatment of tumor-bearing mice could also stimulate α-FR expression in vivo and enhance the tumor Cited by: Dev. Guide: Antifolate Drugs Cancer Therapy, (Ann L. Jackman, ed.) Ch. () “Mendelsohn” Exhibit John F. Worzalla, et al., Role of Folic Acid in Modulating the Toxicity and Efficacy of the Multitargeted Antifolate, LY, Anticancer Res., () “Worzalla” Exhibit L.

Hammond, et al., A Phase I andFile Size: KB. Drug Interactions in Cancer Patients Requiring Concomitant Chemotherapy and Analgesics As more cancer drugs are prescribed in outpatient settings, there is a greater need to ensure that patients are monitored for potential adverse events related to their dual chemotherapy and analgesic regimens.